In his Where AWS IPv6 networking fails blog post, Jason Lavoie documents an intricate consequence of 2-pizza-teams not talking to one another: it’s really hard to get IPv6 in AWS VPC working with Transit Gateway and Direct Connect in large-scale multi-account environment due to the way IPv6 prefixes are propagated from VPCs to Direct Connect Gateway.

It’s one of those IPv6-only little details that you could never spot before stumbling on it in a real-life deployment… and to make it worse, it works well in IPv4 if you did proper address planning (which you can’t in IPv6).